What is the most likely cause?
A.Cyclophosphamide
B.Bleomycin
C. Methotrexate
D. Doxorubicin
Answer and Explanation:
Answer:
B. Sarcoidosis
Explanation:
- The images show uveitis (eye involvement), lupus pernio (violaceous facial lesions), erythema nodosum (tender red nodules on shins), and non-caseating granulomas on histology.
- These are classic features of sarcoidosis, a multisystem granulomatous disease.
Incorrect options:
A. Tuberculosis
•Shows caseating granulomas, unlike the non-caseating granulomas in sarcoidosis.
•Does not present with lupus pernio or erythema nodosum as typical findings.
C. Histoplasmosis
•Histology would reveal intracellular yeast forms within macrophages.
•The clinical triad here (uveitis, lupus pernio, erythema nodosum) is not characteristic.
D. Wegener’s granulomatosis (Granulomatosis with polyangiitis)
•Presents with necrotizing granulomas, systemic vasculitis, respiratory tract and kidney involvement.